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The trick is not to follow the herd. These overlooked companies are now trading for less than their intrinsic value. This is a significant finding which suggests activated STAT3, and therefore associated parts of that signalling pathway, may provide a path towards the identification of a predictive biomarker of response to SFX Led by Chief Investigator Dr Sacha Howell of the Christie Hospital in Manchester, the trial is recruiting 60 patients from multiple sites in the UK, Belgium, France and Spain — seven sites in total are currently open for recruitment across these countries and 18 patients have been enrolled to date.

We are projecting the read-out from the study in the second half of calendar year As the study is open label, the Company will issue an interim data analysis in the first half of calendar year Prior to entry to the STEM trial, patients must have previously responded to their current hormone therapy for at least six months but then present with progressive disease, thereby demonstrating the start of resistance to the hormone therapy. Once entered into the trial, patients continue to receive their hormone therapy in addition to SFX and have regular scans through to week Patients discontinue the trial when one of the scans shows disease progression or at week The Company has initiated a compassionate use programme for patients that have reached week 24 without disease progression so that they can continue to receive SFX The trial is registered at ClinicalTrials.

A delayed cerebral ischaemia DCIwhich happens days after the initial haemorrhage, remains the single most important cause of morbidity and mortality in those patients that survive the initial bleed. The trial is a double-blind, placebo-controlled study of 90 patients; 45 receiving nimodipine and placebo and 45 receiving nimodipine and SFX led by chief investigator Mr Diederik Bulters, Consultant Neurosurgeon. Potential follow-on studies would almost certainly have primary clinical endpoints based on such clinical outcomes. Recruitment has now recommenced at the Southampton centre and a second site, Queen Elizabeth Hospital Birmingham, has been initiated and will commence recruitment when appropriate staffing has been arranged.

We are in discussions to open up to three further sites. The target read-out time from the study is around the end of calendar year Early stage pipeline In collaboration with the medicinal chemists at the University of Seville we have created a range of novel compounds based upon the sulforaphane core structure. Evgen has in-licensed the Seville intellectual property presenting us with multiple new chemical entities based upon sulforaphane. Screening of a series of such novel, proprietary, sulforaphane analogues is underway at the University of Liverpool and the full dataset will be evaluated during Q1 of calendar year Advances in sulforaphane science and investigator-initiated study opportunities The scientific literature around sulforaphane continues to expand with seeing a record number of peer-reviewed publications and now over to date in A number of papers support the hypothesis that sulforaphane targets cancer stem cells; in particular, sulforaphane has been shown to enhance the activity of taxanes against triple negative breast cancer by killing cancer stem cells.

The programme will investigate the effect of SFX with and without chemotherapy on patient-derived triple negative tumours in animal models.

It Evgen st dating funded by a charitable donation from the Shine Bright Foundation, a UK charity focused on triple negative breast cancer, to the University of Manchester. Increasing academic interest in sulforaphane is leading to requests that the Company support investigator-initiated pre-clinical and clinical programmes. We are in dialogue with a number of groups over studies that would broaden the range of applications for SFX with limited financial demands on the Group. Nearer term collaborative opportunities are being developed in stroke pre-clinical and clinicalautism pre-clinical and clinicalglioblastoma pre-clinical and bone regeneration pre-clinical.

Intellectual property update In October, our first European patent for SFX was granted — covering manufacturing and scale-up processes. A composition of matter patent is also pending in Europe.